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Tesamorelin

Tesamorelin

$161.24$201.55

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

Tesamorelin+Peptide Tesamorelin+is+a+synthetic+polypeptide+composed+of+44+amino+acids+analogous+to+growth+hormone-releasing+hormone.+The+N-terminus+of+the+compound+has+been+modified+compared+to+growth+hormone-releasing+hormone,+the+modification+of+which+researchers+suggest+may+lead+to+improved+stability. (1) Tesamorelin+has+been+studied+for+its+potential+mechanism+of+action,+posited+to+be+similar+to+growth+hormone-releasing+hormones+(GHRH)+receptors+located+at+the+anterior+pituitary+gland,+possibly+leading+to+increased+production+and+secretion+of+growth+hormones.+Growth+hormones+may+act+on+several+cells,+including+hepatocytes,+stimulating+the+systemic+synthesis+of+insulin-like+growth+factor-1+(IGF-1).+In+addition,+growth+hormone+may+also+stimulate+IGF-1+production+locally,+inside+various+tissues. (1) Overview IGF-1+has+been+posited+to+be+the+main+anabolic+mediator+of+growth+hormone,+potentially+working+to+stimulate+growth+and+inhibit+programmed+cell+death. (1) +On+the+other+hand,+growth+hormone+itself+is+suggested+to+be+lipolytic,+inducing+fat+breakdown+at+specific+adipose+depots,+such+as+abdominal+and+visceral+fat+depositions.+Tesamorelin+appears+to+stimulate+the+release+of+growth+hormone,+and+consequently+IGF-1,+by+potentially+interacting+with+the+GHRH+receptors+in+the+anterior+pituitary+gland+cells.+When+Tesamorelin+interacts+with+the+GHRH+receptor,+it+is+hypothesized+that+this+interaction+might+alter+the+receptor’s+structure,+potentially+initiating+communication+pathways+within+the+cell.+It+is+also+theorized+that+Tesamorelin+might+enhance+the+production+of+cyclic+adenosine+monophosphate+(cAMP)+in+certain+cells.+This+process+may+occur+through+the+stimulation+of+adenylate+cyclase,+an+enzyme+that+converts+adenosine+triphosphate+(ATP)+into+cAMP.+Increased+cAMP+levels+may+lead+to+the+activation+of+protein+kinase+A+(PKA),+an+enzyme+deemed+critical+for+transmitting+signals+within+cells.+Activated+PKA+may+phosphorylate+various+target+proteins,+triggering+