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SS-31

SS-31

$140.29$175.36

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

SS-31+Peptide SS-31+(Szeto-Schiller-31),+also+known+as+MTP-131,+is+a+tetrapeptide+that+has+garnered+interest+for+its+potential+properties+related+to+mitochondrial+dysfunction. (1) +With+a+unique+characteristic+of+holding+a+cationic+3++charge+at+physiological+pH,+this+molecule+appears+to+permeate+cell+membranes+with+ease+and+potentially+traverses+the+blood-brain+barrier.+It+has+been+suggested+to+rapidly+exit+cells,+despite+not+being+a+substrate+for+P-glycoprotein.+One+of+the+most+researched+attributes+of+SS-31+is+its+potential+to+accumulate+in+the+inner+mitochondrial+membrane+at+concentrations+that+appear+to+be+over+1000+times+greater+than+in+plasma.+There,+the+peptide+may+display+a+potential+affinity+for+cardiolipin,+an+anionic+phospholipid+exclusively+found+in+the+inner+mitochondrial+membrane.+This+binding+has+been+suggested+to+disrupt+the+interactions+between+cardiolipin+and+cytochrome+C,+leading+to+a+reduction+in+the+oxidative+inactivation+of+cardiolipin+by+cytochrome+C.+The+mechanism+may+involve+inhibiting+the+peroxidase+activity+of+cytochrome+c,+while+preserving+Met80-heme+ligation+and+favoring+its+electron+carrier+activity+by+SS-31.+Given+that+cardiolipin+has+been+suggested+to+play+a+pivotal+role+in+optimizing+mitochondrial+electron+transport+and+ATP+production,+this+disruption+has+significant+potential.+It+may+help+in+the+formation+of+mitochondrial+cristae,+ensuring+efficient+oxidative+phosphorylation+and+minimizing+the+leakage+of+reactive+oxygen+species. Chemical+Makeup Molecular+formula:+ C 32 H 49 N 9 O 5 Molecular+weight: +639.8+g/mol Sequence: +D-Arg-dimethylTyr-Lys-Phe-NH 2 Other+known+titles: +MTP-131 Research+and+Clinical+Studies Below+we+have+extracted+information+from+the+latest+clinical+and+preclinical+data+on+the+potential+actions+of+SS-31+as+reported+by+various+research+models. SS-31+and+Oxidative+Stress Oxidative+stress+is+posited+as+the+principal+factor+in+the+development+of+a+wide+range+of+pathologies,+such+as+retino