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Semax

Semax

$72.58$90.73

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

Semax+Peptide Semax+peptide+is+a+synthetic+polypeptide+analog+of+an+adrenocorticotropic+hormone+fragment+4-7+(ACTH+4-7), (1) +a+hormone+secreted+by+the+anterior+pituitary+gland.+This+fragment+has+been+reported+by+researchers+not+to+exhibit+any+action+characteristic+of+ACTH+itself+but+may+have+a+potentially+specific+action+within+the+brain. (2) Researchers+find+that+naturally+occurring+peptides+may+occasionally+exhibit+instability+and+easy+degradation+by+biological+enzymes,+such+as+those+found+in+gastrointestinal+and+cerebrospinal+fluids.+Consequently,+researchers+aim+to+synthesize+analogs+of+these+naturally+occurring+but+potentially+unstable+peptides+to+induce+similar+biological+action+with+the+added+value+of+higher+stability.+Semax+is+one+such+synthetically+developed+derivative+of+an+endogenous+adrenocorticotropic+hormone+fragment.+The+Met-Glu-His-Phe+sequence+in+Semax+is+extended+by+adding+a+Pro-Gly-Pro+(PGP)+sequence+at+its+C-terminal+end.+This+modification+with+PGP+may+potentially+enhance+the+molecule’s+ability+to+cross+the+blood-brain+barrier+(BBB)+by+increasing+its+lipophilicity.+This+increase+in+lipophilicity+may+facilitate+the+molecule’s+passive+diffusion+or+uptake+through+mechanisms+such+as+lipid+raft-mediated+endocytosis,+which+may+circumvent+the+tight+junctions+that+typically+restrict+entry+into+the+brain.+Furthermore,+the+presence+of+PGP+at+the+peptide’s+C-terminus+might+also+modify+its+interactions+with+specific+transporters+or+receptors+on+the+BBB,+potentially+favoring+its+transport+via+receptor-mediated+transcytosis.+Moreover,+the+acetylation+of+Semax+may+improve+its+stability+by+making+it+more+resistant+to+enzymatic+breakdown,+thereby+extending+its+half-life+in+biological+settings. Overview Synthetically+developed+Semax+has+been+widely+researched+for+its+potential+mechanism+of+action+and+lauded+for+its+apparent+biological+stability.+Researchers+suggest+it+may+inhibit+select+enzymes+that+regulate+the+degradation+of+enke