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Selank

Selank

$72.58$90.73

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

Selank+Peptide Selank+is+a+short,+synthetic+heptapeptide+composed+of+seven+amino+acids.+Selank+was+developed+to+mimic+the+naturally+occurring+peptide+Tuftsin, (5) +a+short+fragment+from+the+immunoglobulin+G+(IgG),+a+natural+tetrapeptide+involved+in+certain+biological+functions+that+regulate+the+immune+system.+After+the+discovery+and+initial+isolation+of+Tuftsin,+researchers+suggested+that+the+peptide+might+be+involved+in+the+functions+of+phagocytic+cells,+including+phagocytosis,+motility,+and+immunological+cell+functions. (2) +Since+then,+various+synthetic+analogs+of+Tuftsin+have+been+synthesized+in+laboratories+by+conventional+and+polymeric+reagent+methods. (4) Overview Selank+is+a+peptide+chain+composed+of+two+fragments+–+one+is+Tuftsin+at+the+N-terminus,+and+the+other+is+a+tripeptide+Pro-Gly-Pro+(PGP)+at+the+C-terminal+end+of+the+molecule.+The+inclusion+of+a+Pro-Gly-Pro+(PGP)+sequence+in+the+peptide+Selank+might+enhance+its+potential+to+penetrate+various+biological+barriers,+including+the+blood-brain+barrier+(BBB).+The+BBB+is+a+highly+selective+and+semi-permeable+membrane+that+delineates+the+circulating+blood+from+brain+tissues+and+extracellular+fluid+within+the+central+nervous+system.+It+is+deemed+to+play+a+pivotal+role+in+controlling+the+entry+of+molecules.+Integrating+the+PGP+sequence+might+modify+the+peptide’s+hydrophilicity+or+lipophilicity,+which+might+increase+its+compatibility+with+the+lipid-rich+milieu+of+the+BBB.+Moreover,+the+PGP+motif+might+interact+with+certain+transport+systems+or+receptors+on+the+BBB+membrane,+potentially+facilitating+receptor-mediated+endocytosis+or+active+transport.+These+mechanisms+may+permit+Selank+to+circumvent+the+tight+junctions+that+typically+impede+the+transit+of+larger+molecules+through+the+BBB.+Additionally,+the+presence+of+the+PGP+sequence+might+alter+the+tertiary+structure+of+Selank,+potentially+rendering+it+more+amenable+to+traversing+the+BBB.+This+alteration+might+arise+from+changes+in+the+pep