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IGF-1+LR3

IGF-1+LR3

$141.89$177.36

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

Receptor+Grade+IGF-1+LR3+Peptide Between+1940+and+1950,+the+growth+hormone+ somatotropin +was+identified+and+researched.+It+was+tentatively+suggested+that+this+hormone+might+enhance+sulfate+uptake+in+normal+control+rat+serum,+implying+an+increase+in+amino+acid+uptake+or+synthesis.+However,+this+connection+was+not+definitively+established.+This+so-called+“sulfate+factor”+was+subsequently+isolated+from+the+rat+serum+and+named+“somatomedin.”+Concurrently,+an+independent+study+explored+the+components+responsible+for+producing+insulin-like+activity.+It+was+hypothesized+during+this+investigation+that+these+components+might+be+“somatomedins,”+leading+to+the+designation+of+these+compounds+as+“insulin-like+growth+factors.” (1) Further+explorations+into+the+insulin-like+growth+factors+involved+gene-targeting+approaches+to+potentially+enhance+their+bioavailability+and+potency.+During+these+studies,+a+variant+called+Receptor+Grade+IGF-1+LR3+was+developed.+This+variant+included+an+additional+arginine+residue+and+featured+an+elongated+structure+at+the+N-terminal+(by+13+amino+acids),+resulting+in+a+protein+composed+of+83+amino+acids,+compared+to+the+70+amino+acids+found+in+natural+IGF-1. (1) Receptor+Grade+IGF-1+LR3+peptide,+a+polypeptide+amino+acid+also+known+as+Long+arginine+3+IGF-1,+or+LR3-IGF-1,+has+been+suggested+to+exhibit+potential+action+similar+to+Insulin-like+Growth+factor-1,+or+IGF-1. (2) +IGF-1+is+a+naturally+produced+protein+comprised+of+70+amino+acids.+Structurally+similar+to+insulin,+this+Receptor+Grade+IGF-1+LR3+has+the+potential+primarily+to+regulate+cell+tissue+and+development.+Several+synthetic+variations+of+IGF-1,+such+as+recombinant+IGF-1+(rhIGF-1),+were+developed+to+mimic+the+natural+protein+identically+and+stimulate+similar+actions+as+IGF-1.+Another+example+is+Receptor+Grade+IGF-1+LR3,+which+researchers+speculate+exhibits+an+increased+affinity+and+anabolic+potential+while+binding+less+to+IGF-1+binding+proteins+(IGF-1BPs).+This+variant+has+been+d