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MOTS-C

MOTS-C

$104.82$131.03

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

MOTS-c+Peptide MOTS-c+(mitochondrial+open-reading-frame+of+the+12S+rRNA-c)+peptide+is+a+novel+mitochondria-derived+peptide.+It+is+a+short+peptide+composed+of+16+amino+acids,+expressed+in+tissues+and+plasma,+indicating+a+cell-specific+and+hormonal+role. (1) +With+the+potential+to+work+both+as+a+cell-specific+compound+and+as+a+hormone,+this+peptide+possibly+acts+by+stimulating+the+AMP-activated+protein+kinase+(AMPK)+pathway.+Only+two+mitochondrial-derived+peptides+(MDPs)+have+been+studied,+Humanin+and+MOTS-c.+When+metabolic+stress+occurs+in+the+organism,+the+peptide+is+believed+to+translocate+to+the+cellular+nuclei+and+alter+the+gene+expression.+MOTS-c+peptide+may+also+be+released+extracellularly+and+is+known+as+“ mitochondrial+hormone ”+or+simply+as+“ mitokine. ”+ (2)(3) Chemical+Makeup (4) Molecular+Formula: +C 101 H 152 N 28 O 22 S 2 Molecular+Weight: +2174.64+g/mol Other+Titles: +Mitochondrial-derived+peptide+MOTS-c,+Mitochondrial+open+reading+frame+of+the+12S+rRNA-c Research+and+Clinical+Studies Animal+research+models+have+indicated+multiple+potential+actions+from+MOTS-c+peptide,+including+increased+physical+performance,+regulated+cellular+and+tissue+metabolism,+and+myoblast+adaptation. (2) +Research+suggests+that+these+actions+may+primarily+depend+on+age+and+age-related+changes+in+MOTS-c+expression.+The+researchers+suggest+MOTS-c+levels+and+activity+might+decline,+hinting+at+a+role+in+the+cell+aging+process+and+the+development+of+age-related+metabolic+dysfunction.+Furthermore,+MOTS-c+may+interact+with+known+aging+regulators,+such+as+NAD++and+sirtuins,+suggesting+its+involvement+in+pathways+potentially+modulating+the+lifespan+of+the+cell. (1) +As+per+Joseph+C+Reynolds+et+al.,+ “Mitochondria+are+chief+metabolic+organelles+with+strong+implications+in+cell+aging+that+also+coordinate+broad+physiological+functions,+in+part,+using+peptides+that+are+encoded+within+their+independent+genome.” (4) +The+peptide+endogenous+expression+has+also+been+posit