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Kisspeptin-10

Kisspeptin-10

$85.48$106.85

In stock: 100

Research use only. These products are sold for research purposes only, not for human use. Product comes as lyophilized powder and must be reconstituted before use.

Description

Kisspeptin-10+Peptide Kisspeptin-10+is+a+naturally+occurring+peptide+protein+encoded+by+the+KISS1+gene. (2) +Kisspeptin+is+a+product+of+the+KISS1+gene,+produced+by+the+cleavage+of+the+original+145-amino+acid+polypeptide+to+a+smaller+peptide.+This+smaller+peptide,+composed+of+54-amino+acids,+is+cleaved+further+to+become+Kisspeptin+45-54,+also+known+as+Kisspeptin+10. (6) KISS1+is+a+gene+that+is+considered+to+suppress+metastases+of+melanomas+and+breast+carcinomas,+thereby+inhibiting+abnormal+cell+growth+and+potentially+preventing+cancer. (2) +Initially+considered+to+be+a+metastasis+suppressor,+Kisspeptin-10+was+later+suggested+to+possess+a+different+expression+profile,+which+may+potentially+allow+it+to+function+on+the+hypothalamus+and+pituitary+gland,+thereby+impacting+the+reproductive+system. (3) Several+independent+studies+in+the+mid-2000s+suggested+that+Kisspeptin-10+may+play+a+role+in+hypogonadotropic+hypogonadism,+as+the+peptide+is+considered+to+be+a+ligand+of+the+G-protein+coupled+receptor+54+(GPR54). (5)+ Research+continues+to+explore+this+potential+aspect+of+the+Kisspeptin-10+peptide. Hypogonadism+is+a+system+disorder+wherein+reproductive+organs+produce+less+or+no+sex+hormones.+One+of+the+forms+of+hypogonadism+is+called+hypogonadotropic+hypogonadism,+where+the+organism+suffers+from+hypogonadism+due+to+under-functioning+of+the+pituitary+gland+or+hypothalamus. (1) +GnRH+is+considered+to+stimulate+the+pituitary+gland+to+release+follicle-stimulating+hormone+(FSH)+and+luteinizing+hormone+(LH).+Both+FSH+and+LH+are+considered+to+regulate+reproductive+function. (1) +Lack+of+these+hormones,+i.e.+GnRH,+FSH,+and+LH,+are+considered+the+main+factors+of+hypogonadotropic+hypogonadism. Overview GPR54,+also+called+the+KISS1+receptor+(KISS1R), (7) +has+been+suggested+by+researchers+to+be+an+important+GnRH+receptor. (1) +They+further+suggest+that+Kisspeptin-10+exhibits+action+by+possibly+binding+to+GPR54+receptors,+which+may+activate+the+reproductive+axis+by+st